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Dr. Karl E. Peace Receives Notable Book Reviews

Peace2Dr. Karl E. Peace, Professor of Biostatistics and Georgia Cancer Coalition Distinguished Cancer Scholar at the Jiann-Ping Hsu College of Public Health Georgia Southern University, receives notable reviews (1,2) of one of his twelve published books.

This book aims to provide a thorough overview of the design, analysis, and interpretation of clinical trials in which the time to an event is the critical endpoint (e.g. death in cancer treatment studies; serious adverse event (AE) in drug safety studies. Although this book is a compilation of contributions by various authors, it is less heterogeneous than one might expect. However, being a compilation, this is not the standard textbook that you want to get in order to learn time-to-event analysis.

Several of the Chapters are written by Dr. Peace himself; e.g. Chapter 12. Using antibiotic trials as an example, he shows that some methods which compare the status of a patient at the end of a given time (in this example the micro-biotical cure and the clinical cure) neglect the time to cure. Peace gives a practical example of a trial where the time to cure was taken into account. Overall a rather short chapter but a good reminder that when designing a trial one should ask the question “does time matter” more often.

Overall, this book provides a good overview of problems one may face when having to deal with time-to-event data and how these could be handled. Furthermore it gives examples of where time-to-event data are currently not analysed with time-to-event methods, notably AE data. Although there are some points for critique and some chapters fall behind others in terms of quality or appropriateness, and I feel that some topics would deserve more space, I would recommend this book to every practitioner who has to deal with time-to-event data. The reader can easily skip chapters that are not relevant but those chapters that are relevant will justify purchasing this book (1).

… One of the strengths of the book is the collection, discussion and illustration of the many diverse time-to-event problems that may occur in practice. … this publication provides a comprehensive overview of classical and emerging ideas in the analysis of time-to-event problems. Written by experts in their area, the book has a wealth of references in each topic should the reader wish to learn about or extend their understanding of individual concepts or analysis methods. It is a worthwhile book to have in the library for anyone working in designing, conducting, analysing or interpreting studies with time-to-event outcomes (2).

  1. Herpers, M (2016): Book Review of Design and Analysis of Time to Event Data with Time to Event Endpoints by Karl E. Peace. ISCB NEWS, pp. 30, 31, Number 61, June 16, 2016.
  1. Australian & New Zealand Journal of Statistics, 2011: https://www.crcpress.com/Design-and-Analysis-of-Clinical-Trials-with-Time-to-Event-Endpoints/Peace/p/book/9781420066395

 

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Posted in Biostatistics, faculty-highlights, JPHCOPH, JPHCOPH, KEPeace CBSR